The aim of this study to investigate the influence of administration of grape seeds as an antioxidant on the blue light effects induced in retinal sensitivity. The a-& b-waves of rabbit electrorentinogram (ERG) were measured after different periods (2, 7, 14 and 21 days) of blue light exposure. The obtained results indicated that the blue light had an apparent effect on both a& b-waves .That was in the form of a decrease in their amplitudes and increase in their implicit time. This effect increased for longer exposure period of blue light. However, the most striking feature in the ERG wave form variations appeared in case of the longest exposure time (21 days) where a negative ERG is recorded. This Type of ERG reflects the non-vitality of the retina due to the photo-chemical damage of blue light. After administration of grape seeds, there was a type of improvement in the ERG parameters towards control values but they were still lower than the control. However, no improvement appeared in the recorded negative ERG, and in this case the grape seed has no effects. It is concluded that long exposure to blue light affects the high order retinal neurons and this may be considered as a permanent effect. Accordingly, the grape seeds may have a neuroprotective effects that help in protecting the retinal neurons against photo chemical damage which may induce retinal cell death. So, the administration of grape seeds can help in protecting the retina. [Elawady A Ibrahim and El-hansi N Mohmed Neuroprotective Effects of Grape Seeds against Photo-Chemical Damage–Induced Retinal Cell Death] Nature and Science 2011; 9(11):83-89]. (ISSN: 1545-0740). http://www.sciencepub.net.
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