Preparation and Characterization of Nabumetone Liposomes


Nabumetone is the effective drug for the treatment of reumatoid arthritis and osteoarthritis. The drug has a half life of 23 hrs and its oral bioavailability is only 30%. The aim of the study is to prepare 6 formulations of liposomal carrier for Nabumetone for the treatment of arthritis that is capable of delivering the drug to the specific target site by topical route by using different ratios of phospho lipid and cholesterol with a desired amount of drug by thin film hydration technique and to find out the drug release from the liposome's of different ratios, mechanism kinetics of drug release pattern and also to find out the size distribution of liposome's of different ratios and also to increase the bioavailability and efficacy of the drug.


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